![]() ![]() Insects possess well-developed and species-specific color patterns, displaying a strikingly colorful animal kingdom. mori has a unique side branch in the kynurenine pathway, distinctly different from other insects. We conclude that T102I in BmKYNU causes the red body coloration in the rb strain. Additionally, linkage analysis indicated that no recombination between rb and BmKynu was detected. Our results clearly showed that a point mutation (T102I) in BmKYNU of the rb strain led to a marked decrease in KYNU activity, presumably resulting in abnormal accumulation of 3-hydroxykynurenine. Therefore, BmKynu is the first KYNU gene observed in insects. KYNU has been identified in microorganisms and animals but not in insects. Kynureninase (KYNU) hydrolyzes kynurenine and 3-hydroxykynurenine to anthranilic acid and 3-hydroxyanthranilic acid, respectively. Here, we provide evidence that the rb gene corresponds to a novel bacterial-type kynureninase gene, BmKynu. However, the gene responsible for the rb phenotype is not yet known. The irregular coloring was assumed to result from an abnormal accumulation of 3-hydroxykynurenine. Larvae of the body color mutant red blood ( rb) of the silkworm, Bombyx mori, display reddish skin whose hemolymph becomes red in air, whereas hemolymphs of normal strains become black during melanization. ![]()
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